During the war 434 men were discharged and 40 officers resigned from the 3rd Michigan on account of a disability of one type or another. Another 65 men from the Old 3rd who had been consolidated into the 5th Michigan were discharged for disability. Altogether some 539 or more than 38% of the total enrolled were discharged for disability. At least 42 men suffered the loss of a limb.
Some of the more common disabilities reported were:
Asthma, bronchitis, consumption, deafness, dysentery, epilepsy, gunshot, heart disease, hemorrhoids, hernia, measles, pneumonia, rheumatic fever, rheumatism sunstroke, trauma or accident, typhoid fever, varicose veins and venereal disease